Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment
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منابع مشابه
Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment
In the early twentieth century, Otto Heinrich Warburg described an elevated rate of glycolysis occurring in cancer cells, even in the presence of atmospheric oxygen (the Warburg effect). Recently it became a therapeutically interesting strategy and is considered as an emerging hallmark of cancer. Hypoxia inducible factor-1 (HIF-1) is one of the key transcription factors that play major roles in...
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That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...
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That slices of tumor tissue will produce large amounts of lactic acid has been well known since the early studies in Warburg's laboratory in 192430 (10, 20). That tumor glycolysis involves the same intermediate pathway as found in normal tissues has, however, been frequently questioned, perhaps most recently by Salter who re-emphasized at the Hershey Conference on Intracellular Enzymes in Norma...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/354143